Scientific journal

European Journal of Natural History

ISSN 2073-4972

ИФ РИНЦ = 0,301

Functionality class

Clinical and laboratory characteristics

Limitation of life activity

1

2

3

FC 1

(0-25 %)

• Asymptomatic flow
• Persistent generalized lymphadenopathy (PGL)
• Level CD4 – клеток более 25 %

Level RNA HIV < 10 000 copies/ml (in children older than 5 years)

Self-service-FC0

Orientation-FC0-1

Communication-FC0-1

Training-FC0-1

Behavior Monitoring -FC0-1

Motor activity-FC0-1

Table continuation

1

2

3

FC 2

(26-50 %)

• Moderate disruption of physical development, nutrition for no apparent reason, not responding to standard therapy
• Hepatosplenomegaly
• Papular pruritic rashes on the skin
• Seborrheic dermatitis
• Onychomycosis
• Angular Cheilitis
• Marginal gingivitis
• Recurrent ulcers of the oral cavity (2 or more cases within 6 months)
• Increased parotid gland
• Recurrent or chronic infections of the upper respiratory tract or middle ear
• Herpes zoster

I Laboratory test data:

ALT – increase to 3 norms

γ – globulins – from 8 % to 14 %

PCR – detection in the blood DNK VSV, CMVI, candida

ELISA – specific antibodies of HSV, CMV, candida

Immunological study – the level of CD4 cells – 20-24 %

HIV RNA level < 20 000 copies / ml (in children over the age of 5 years)

II Ultrasound of the liver – hepatomegaly moderate, moderate diffuse changes in the liver parenchyma, enlarged portal vein.

Self-service-

FC1-2

Orientation – FC1-2

Communication – FC1-2

Training-FC1-2

Behavior Monitoring – FC2-3

Motor activity – FC1-2

FC 3

(51-75 %)

• Severe impairment of physical development, nutrition, not responding to standard therapy
• Unexplained lingering diarrhea (> 14 days)
• Unexplained lingering fever (> 1month)
• Candidiasis of the oral cavity (in children older than 2 months)
• Hairy leukoplakia of the mouth
• Pulmonary tuberculosis
• Severe recurrent, prolonged bacterial pneumonia (2 or more episodes in 6 months)
• Acute necrotizing ulcerative gingivitis / periodontitis ? LIP (lymphoid Ipterstic pneumonitis)

I. Laboratory test data:

Anemia (< 80g / l), neutropenia (< 1000l / ?l) or thrombocytopenia (< 100 000l / ?l) for 1 month or more

• ALAT – increase from 3 to 5 minutes
• γ-globulins – from 6 % to 8 %
• PCR – detection in the blood of DNA of HSV, CMV, Toho, candidiasis and other infections
• ELISA – specific antibodies of HSV, CMV, Toxo, candida and other infections
• level of CD4 cells – 15-19 %
• HIV RNA levels – more than 20 000 to 55 000 copies / ml (in children over the age of 5 years)

II. X-ray – upper-left infiltrate, atypical manifestations

• Radiographically – two-sided low-annual (more often interstitial,
• less often reticulonodular) infiltrates

(LIP clinic)

• Ultrasound of the liver – hepatomegaly expressed, mild fibrosis with portoportal septums.
• Sputum boobs – detection of mycobacterium tuberculosis

Self-service -

FC2-3

Orientation – FC2-3

Motor activity – FC2-3

Communication – FC2-3

Education – FC2-3

Behavior Monitoring – FC2-3

End of table

1

2

3

FC 4

(76-100 %)

Severe depletion or other form of eating disorders, physical development not responding to standard therapy

• Pneumocystis pneumonia
• Recurrent severe, bacterial infections (2 or more episodes per year)
• Chronic skin or area around the mouth, caused by HSV (more than 1 month)
• Candidiasis of the esophagus, trachea, bronchi or lungs
• Disseminated or extrapulmonary tuberculosis
• Kaposi’s sarcoma
• Toxoplasmosis of the central nervous system
• Any disseminated endemic mycosis, including cryptococcal meningitis
• Cytomegalovirus infection in a child older than a month (outside the liver, spleen and lymph nodes)
• Visceral herpes
• HIV-encephalopathy

Lymphoma of the central nervous system or B-cell lymphoma

• Progressive multifocal leukoencephalopathy
• Cardiomyopathy due to HIV
• Nephropathy due to HIV
• Leukemiosarcoma or other HIV-associated solid tumors

I. Laboratory test data:

• The general analysis of blood – anemia (Hb 70,0 g / l and below), leukocytes <3,0 * 109, lymphopenia
• ALAT – increase in excess of 5 norms
• γ-globulins – from 4 % to 6 %
• PCR – detection in the blood, in cerebrospinal fluid of HSV, CMV, Toho, candidiasis and other infections
• ELISA-specific antibodies of HSV, CMV, Toxo, candida and other infections
• Reduction in CD4 count < 15 %
• HIV RNA levels – more than 55 000 – 100 000 copies / ml (in children over the age of 5 years)

II. Rentgenologically – bilateral reticulonodular infiltrates, more pronounced in the radical zone and extending around the periphery, an abundance of focal shadows – a “cotton” radiograph (PCP clinic)

• Ultrasound of the liver – fibrosis with portoportal septums.
• MRI, CT – foci of meningoencephalitis, demyelination in the hemispheres or in the brain of the posterior cranial fossa

Self-service -

FC3-4

Orientation – FC3-4

Communication – FC3-4

Training – FC3-4

Behavior Monitoring – FC3-4