Scientific journal
European Journal of Natural History
ISSN 2073-4972
ИФ РИНЦ = 0,301


Tayzhanova D.Z. 1 Toleuova A.S. 1 Guseinova Z.K. 1 Bekmagambetova Z.B. 1
1 Karaganda State Medical University

Patients with a narcomania are a group of high risk of hepatitis B (HBV) and hepatitis C (HCV) development. They are consisting a peculiar tank for the diffusion of narcotic and virus epidemic [1]. The toxic influence of narcotic preparations, infection by hepatitis B and C viruses or their combination, of narcotics intravenous administration promotes pathological process in a liver. The hepatitis C virus has the highest chroniogenic potential and is the main reason of all groups of a chronic liver disease formation– chronic hepatitis, cirrhosis, hepatocellular carcinoma [2].

Research aim is the assessment of hepatotropic viruses (B and C) infection degree in groups with high risk where finding injection narcomaniacs.

Materials and research methods. We are observed 113 narcomaniacs consuming opium intravenously in a number of 2,0–3,0 grams daily. Middle age of opiomaniacs is 24,6 ± 1,6 years old (from 19 to 39 years). The majority of observed were males (85,1 %), only 14,9 % – female.

It was used diagnostic immune enzyme test-system. It is a set of the components the basis of which was recombinant antigens of the hepatitis C virus, corresponding to the HCV genome proteins coded sites. For identification of a hepatitis B virus antibodies and antigens applied also a reagent set. The principle of it was consisted in the interaction of antibodies to HCV with the antigens immobilized in the small cavities of a polystyrene tablet. Formation of an antigen antibody complex was discovered by the serum immune enzyme conjugate which yielded primary positive results. Then repeatedly was checked in a confirming test strip. The immune enzyme analysis, it was spent on a Sanoti Paster spectrophotometer.

Results and discussions. The analysis of HCV and HBV infection of frequency testifies to their high prevalence among injection narcomaniacs: HВsAg – 18 %, HВeAg-6 %, anti-HВcIgM – 17,6 %, anti-HВe – 45 %, anti-HBs – 43 %, and anti-HВcIgG – 19,6 %. It should be noted at the 6 % of narcomaniacs with chronic hepatitis was found anti-HВcIgM and HBsAg combination that testified about the condition of HBV replication. Anti-HВcIgG is defined at the 19,6 % of narcomaniacs and it was criterion of the acute virus hepatitis transferring. Expressed frequency (45 %) anti-HBV at opium consumers excluded of HBV replication activity practically at a half of patients. Thus, it wasn’t excluded infected by a mutant form of a virus.

It is noted high HCV infection of the injection narcomaniacs. So, anti-HCV – positive observed patients appeared 83,1 %. Thus, the frequency of HCV depended on opium consumption, duration: at narcomaniacs lasting narcomania of 1 year – anti-HCV – positivity is revealed at 33,3 %, with the term of opium intoxication 2–3 years – at 41,4 % and lasting 4–5 and more than years – at 83,9 %. There are data that the average duration of the chronic hepatitis C formation after an initial infection deviates from 10,0 ± 11,3 to 13,7 ± 10,9 years and in 20 years at 20 % of such patients develops cirrhosis and a hepatocellular carcinoma [3].

Thus, the special attention is deserved by the fact of high frequency of circulation of virus hepatitis B and C markers at narcomaniacs of young age, and extent of HCV infection directly depends on of a narcotization experience and is progressively enlarged in process of narcotic intoxication time elongation.