«Golden Section», that is, division into shares of a 0,618 and 0,382, seen in many publications as normal in the body. Deviation from it as indicating the presence of disease.
This article analyzes the morphological changes in the liver of mice exposed to magnetic fields from the standpoint of the «golden section». The experimental data suggest that the law of the «golden section» is applicable not only in normal conditions, but under severe pathological processes. This indicates the tendency of a biological substance to equilibrium in mature irreversible pathological process.
The purpose of the study. The aim of the study was to analyze the severity of the morphological changes in the liver of mice exposed to magnetic fields of different modes from the standpoint of the «golden section». Reviewed the results of the study of the morphological effects of the control actions extremadamente low-frequency, rotating magnetic fields (EMF) and impulse traveling magnetic fields (IBMP) to mammalian tissue.
Materials and Methods. To verify compliance with the law «golden mean» for a number of indicators or deviation from it was carried out in five groups of laboratory animals:
Group 1 – control group of intact mice;
Group 2 – the experimental group of mice that were exposed to a traveling magnetic field pulse (IBMP) with a pulse duration of 0,5 seconds;
Group 3 – the experimental group of mice that were exposed to a rotating magnetic field (EMF) with a frequency of 6 Hz, the direction of rotation of the field to the right, the magnetic induction 4 mT, combined with an alternating magnetic field (VMF) at 8 Hz, at a value 4 mT magnetic induction;
Group 4 – experimental group of mice that were exposed to an alternating magnetic field (VMF) at 8 Hz when the magnetic induction 4 mT;
Group 5 – the experimental group of mice that were exposed to EMF with a frequency of 6 Hz, the direction of rotation of the field to the right, the magnetic induction 0,4 mT, combined with an alternating magnetic field (VMF) with a frequency of 8 Hz, the magnetic induction 0,4 mT.
The results of research. Analyze from the standpoint of the «golden section» relations between some morphometric parameters of liver tissue. Analysis were the following parameters: the size of the central vein, the area of the cytoplasm in the area of necrosis and the area of the central vein, the area of necrosis and the area of the central vein as indicators, reflecting the state of hemodynamics at the microcirculatory level in the liver tissue. The values given in Table 1, show that the «golden section» is most characteristic of the fifth group, which has the greatest pathological changes.
The ratio between the area of the cytoplasm in the area of necrosis and the area of the central vein satisfies the law of «golden» for the second (0,410 and 0,590), fourth (0,397 and 0,603) and fifth groups (0,368 and 0,632). The same result is obtained for the ratio between the area of necrosis and the area of the central vein. For the second group, the ratio is 0,389 and 0,611 for the fourth – 0,359 and 0,631, for the fifth – 0,349 and 0,651. The relation between the size of the central veins close to the «golden» numbers for the fifth group (0,595 and 0,605).
The work was submitted to International Scientific Conference «Innovative medical technologies», Russia (Moscow), 20-22, November, 2012, came to the editorial office on 30.10.2012.