The work is dedicated to the study of functional activity of thrombocytes (Tr) when Q-fever during different periods of the disease. During period 2006- 2009 there were examined 69 patients aged 41,7±3,2 with the diagnosis of Q-fever, confirmed in all cases by serological methods and PCR. The aggregative activity of blood platelets was detected on aggregation analyzer SPF BIOLA (model 230 LA) with AGG software.
In the period of height of disease in 73% of cases the quantity of Tr decreased to 95,4± 4,8х109/l. Influenced by adenosinediphosphate aggregation inductor in concentration 2,5 µm, the aggregation extent was four times lower than normal ranges, but aggregation speed was 1,5 times higher. Aggregate radius reached 4,8±0,27 and that 1,3times less the control one. In the majority of cases (83,4%) aggregatograms were two-wave, but the duration of functional activity of Tr decreased 3΄14˝. In the period of recovery the quantity of Tr was restored to normal ranges, but the aggregation extent was 2 times increased and speed -7 times comparing with the control one. Sizes of aggregates were growing substantially.
Thus, thrombocytic hemostasis link changes, connected not only with the blood platelets quantity decrease, but also their functional activity change, is specific when Q-fever. For the period of height of disease decrease of their functional activity is specific, and in the period of resolution of clinical symptoms of the disease- increase, which may be initiating agent to thrombogenesis.
The work is presented for an International Science Conference "Contemporary issues of experimental and clinic medicine". Thailand, Bangkok-Pattaya, December 20-30, 2009. Received by the editorship on 14.11.2009.