Introduction: Dioxins are known to have a high level of cumulative activity. Because of this they are hazardous not only during contact period. Negative processes in all bodily organs and functional systems occur within the lifetime.
Most scientists believe that the presence of dioxins inside the parental body has large effects on health of the offspring. The most convincing studies were conducted in Yusho and Yu-Cheng (1-5). The effects of accidentally consumed rice oil contaminated with TCDD on the regional population health were related to reduced birth weight, height, skin hyperpigmentation, retarded growth and psychoemotional development, impaired memory, hypoplasticity, abnormal finger and toenails. In Yusho, children born to mothers exposed to dioxin, died from cardio-vascular pathology. However, the authors themselves consider the results obtained to be associated with a variety of factors. In rice oil TCDD was not found alone, it contained a mixture of different chemicals.
Materials and Methods: We have been following a closed cohort of subjects exposed to TCDD during the manufacture of 2,4,5 T between 1965 and 1967. The mean age of the subjects when they developed chloracne was 23±2,3 years. During contact period and after it, 103 children were born to the families exposed to dioxin. During a recent four year period, 2004 - 2006, a complex pediatric health study including questionnaire on working and living conditions, quality of life, health self-assessment was conducted. The individuals who wished to be studied by physicians were offered a complex clinico-functional examination. Thirty subjects were clinically examined by various hematological, biochemical, immunological professionals.
Figure. 1. Dioxin content in subjects exposed by chlorinated doses of TCDD, in their children and population
Results and Discussion: All the children of the cohort are at the age of 24-39 years. Of importance is the fact that there is a 1,2-fold elevation in the number of female children compared with male children. Among subjects aged 35-39 years who were born during contact and early post-contact period this disbalance is 2,0 (66% of females, 34% of males). Gender disproportion of newborn babies was determined in our previous studies (1990-1995).
According to the Republican Centre for Ecology (6), parental TCDD mean concentration is currently determined to be 104,2 pg per gram of blood lipid.
TCDD concentration from 31 to 80 pg per gram of blood lipid is found in the body of the children, confirming the hereditary fact. The mean level of dioxin in the pediatric group is 55 pg per gram of blood lipid that is 2 times greater than the background index of the Russian Federation population (6) (fig.1).
By the time of Stage I study (1990-1995), the children born with background chloracne during post-contact period reached the age of 15-26 years. The mean age was 20±2,2 years. Only every other person among them was regarded to be healthy. (Table 1)
Table 1. illustrates characteristics of the cohort children´s health (%)
|
Signs |
1st child |
2-nd child |
3-d child |
4-th child |
All children |
|
Healthy |
36,6 |
55,6 |
70,0 |
100,0 |
51,7 |
|
Sick, including |
63,4 |
44,4 |
5,0 |
- |
48,3 |
|
Allergy |
7,0 |
6,7 |
10,0 |
- |
7,9 |
|
Chronic bronchitis |
4,2 |
6,7 |
- |
- |
5,3 |
|
Arterial hypertension |
1,4 |
4,4 |
- |
- |
0,8 |
|
Gastritis, ulcer |
7,0 |
6,7 |
- |
- |
7,0 |
|
Cholecystitis |
1,4 |
- |
- |
- |
0,8 |
|
Endocrine disorders |
2,8 |
- |
- |
- |
1,7 |
|
Other disorders |
41,0 |
20,0 |
20,0 |
- |
25,8 |
|
Mean number of disorders per patient |
1,5 |
1,0 |
1,0 |
- |
1,2 |
Clinico-functional health levels of children who underwent clinically-based examination were compared with analogous levels of their parents who had a history of dioxin exposure with marked chloracne. Previous diagnoses of parents aged 26-35 years were observed. We report here the recent diagnoses (1995-2000) with parental age to be over 60 years. Some of them died. (Table 2)
Table 2. Comparison of diagnoses of children and their parents exposed to TCDD chlorinated doses
|
Parental diagnoses |
Pediatric diagnoses |
||
|
Studies between 1968-1980 |
Studies between 1995-2004 |
Studies between 2004-2006 |
|
|
1. |
Hypertension. Vegeto-vascular dystonia |
Vegeto-vascular dystonia. Hypertension. |
Vegeto-vascular dystonia. Ch.gastritis |
|
2. |
Vegeto-vascular dystonia. Ch. gastritis |
Atherosclerosis of heart & brain vessels. Cancer of larynx |
Vegeto-vascular dystonia. Ulcer |
|
3. |
Vegeto-vascular dystonia. Hypertension |
Hypertension. Myocardial infarction |
Vegeto-vascular dystonia |
|
4. |
Vegeto-vascular dystonia. Ch. gastritis |
Hypertension. Encephalopathy |
Vegeto-vascular dystonia. Ch.gastritis |
|
5. |
Vegeto-vascular dystonia. Ch. Bronchitis |
Ischemic heart disease. Hypertension. Ch. bronchitis |
Vegeto-vascular dystonia |
|
6. |
Vegeto-vascular dystonia. Ch. bronchitis |
Hypertension. Cerebrosclerosis. |
Hypotheriosis. Hypophysial insufficiency. Myocarditis. Ch.bronchitis, cholecystitis. |
|
7. |
Vegeto-vascular dystonia. |
Ischemic heart disease. Angina pectoris. Hypertension. |
Vegeto-vascular dystonia. |
|
8. |
Vegeto-vascular dystonia. Ulcer. |
Ischemic heart disease. Angina pectoris. Hypertension. |
Vegeto-vascular dystonia. Hypertension |
|
9. |
Vegeto-vascular dystonia. Ch. gastritis |
Hypertension. Ch. gastritis. Ch.cholecystitis. |
Vegeto-vascular dystonia. Ulcer |
|
10. |
Vegeto-vascular dystonia. Ch. Gastritis. Ch. cholecystitis |
Vegeto-vascular dystonia. Hypertension. Ch.gastritis. Ch. cholecystitis |
Vegeto-vascular dystonia. Ch.gastritis |
|
11. |
Vegeto-vascular dystonia. Ch. Gastritis. |
Hypertension. Ch. gastritis |
Vegeto-vascular dystonia. Ch. Gastritis |
|
12. |
Vegeto-vascular dystonia |
Ischemic heart disease. Hypertension. Myocardial infarction |
Vegeto-vascular dystonia. Ch.gastritis |
|
13. |
Vegeto-vascular dystonia. Ch. cholecystitis |
Hypertension. Ch. gastritis. Ulcer |
Mitral valvular disease. |
|
14. |
Hypertension |
Ischemic heart disease. Hypertension |
Vegeto-vascular dystonia. Encephalopathy. |
|
15. |
Vegeto-vascular dystonia. Arterial hypertension. |
Encephalopathy |
Vegeto-vascular dystonia. Ch.gastritis |
|
16. |
Vegeto-vascular dystonia. Ch. gastritis |
Hypertension. Ch. gastritis |
Vegeto-vascular dystonia. Ch.gastritis |
|
17. |
Vegeto-vascular dystonia. Ch. Gastritis. Arterial hypertension. |
Hypertension. Ch. gastritis |
Vegeto-vascular dystonia. Ch.gastritis. Ch. cholecystitis. |
|
18. |
Vegeto-vascular dystonia. Arterial hypertension. |
Ischemic heart disease. Hypertension. Myocardial infarction |
Erythema nodosum. Ulcer. Arterial hypertension |
|
19. |
Vegeto-vascular dystonia. Arterial hypertension. |
Vegeto-vascular dystonia. Hypertension. Ch.gastritis |
Vegeto-vascular dystonia. Ch.gastritis |
|
20. |
Vegeto-vascular dystonia. Ch. Gastritis. Arterial hypertension. |
Vegeto-vascular dystonia. Ch. bronchitis |
Vegeto-vascular dystonia.Ch.bronchitis Arterial hypertension |
|
21. |
Hypertension. Ch. gastritis. |
Ischemic heart disease.Hypertension. Ch. gastritis. |
Vegeto-vascular dystonia. Ch.gastritis Arterial hypertension |
|
22. |
Hypertension. Ch. gastritis. Arterial hypertension. |
Hypertension. Ch. gastritis. Ch. cholecystitis |
Vegeto-vascular dystonia. Ulcer. Arterial hypertension
|
|
23. |
Vegeto-vascular dystonia. Arterial hypertension. Ch. pyelonephritis |
Ischemic heart disease. Hypertension. |
Vegeto-vascular dystonia.Ch.bronchitis Arterial hypertension |
|
24. |
Vegeto-vascular dystonia. Arterial hypertension. |
Ischemic heart disease. Hypertension. Ch. gastritis. |
Vegeto-vascular dystonia. Ch.gastritis Arterial hypertension |
|
25. |
Vegeto-vascular dystonia. Arterial hypertension. |
Ischemic heart disease. Hypertension. Myocardial infarction |
Vegeto-vascular dystonia. Arterial hypertension. |
|
26. |
Vegeto-vascular dystonia. Arterial hypertension. Ch.gastritis |
Ischemic heart disease. Hypertension. Ch. gastritis. |
Polyvalent allergy |
|
27. |
Vegeto-vascular dystonia. Arterial hypertension. |
Ischemic heart disease. Hypertension. Myocardial infarction |
Vegeto-vascular dystonia. Ch. Gastritis |
|
28. |
Vegeto-vascular dystonia. Artwerial hypertension. Ch. gastritis. |
Ischemic heart disease. Hypertension. Ch. gastritis. |
Vegeto-vascular dystonia. Ch.gastritis. Ch. bronchitis |
|
29. |
Vegeto-vascular dystonia. . Arterial hypertension.Ch. gastritis. |
Ischemic heart disease. Hypertension |
Vegeto-vascular dystonia. Ch. Gastritis |
|
30. |
Vegeto-vascular dystonia Arteria Hypertension. Ch. gastritis |
Hypertension. Ch. gastritis |
Vegeto-vascular dystonia. Ch. Gastritis |
Comparative analysis showed that parental diagnoses established in young life (matching in age with the children) were not different from pediatric ones. It is reasonable to suggest that in later life the children will develop the same diseases as their parents have.
Questionnaire information on health revealed that 51,1% of respondents considered themselves to be "practically healthy" and 48,9% were "sick", respectively. The most common complaints were headache - 58,4%, dizziness - 42,2%, bitter taste in the mouth - 26,6%. Analysis of the answers to the question "What troubles you?" revealed that 21,1% of subjects had cardio-vascular disease, 18,4% - the neuro-system disorders, 14,3% - digestive disorders, 11,9% - respiration disorders, 4,3% - endocrine disorders. Of importance is the fact that hypertensive disease, arterial hypertension, vegeto-vascular dystonia of hypertensive type, neuro-vascular dystonia constitute the group of cardio-vascular and nervous system diseases. It should be noted that the rate of cardio-vascular pathology accompanied by hypertension is about 3 times (2,8) higher among the children of the exposed parents than among the general adult population of the Republic of Bashkortostan. Our previous studies (7) showed cardio-vascular, atherogenic effects of dioxins on parents enrolled in our closed cohort we have been following since 1968.
Thus, our comparative studies have shown that the children of subjects who had chloracne have the same health disorders as their parents.
References:
- Vysochin V.I. Dioxin and relative compounds Analytical review (USSR AS - Novosibirsk - 1989. 153 p.
- Shecter A., Papke O., Lis A. Dioxin Dibenzofuran Elevation in Humans Following Exposure in Yusho // Dioxin´ 93, Vol.13, P. 85-89.
- Lai t., Guo Y.L., Chen S.J. Cognitive Development in Yucheng Children // Dioxin´ 94. 1994. Vol. 1. P.513-517.
- Larri L. Nidkhem. Historic studies of Yuchen accident // Dioxin´93. Vol. 14. P. 231.
- Westings A. Reproductive epidemiology // London Taylor Francis. 1999.
- Amirova Z.K., Kruglov E.A. Dioxin situation in the Republic of Bashkortostan. - Ufa, 1998. 115 p.
- Basharova G.R. Medico-biological consequences of dioxins. Ufa, 2002. 247 p.
The article is admitted to the International Scientific Conference "Prospects of development of a high school science", Sochi (Dagomys), September, 20-23th 2007, came to the editorial office on 14.06.07
Библиографическая ссылка
Karamova L.M., Basharova G. Pyanova F.Z. COMPARATIVE CHARACTERISTICS OF HEALTH STATUS OF PARENTS // European Journal of Natural History. – 2007. – № 4. – С. 132-136;URL: https://world-science.ru/ru/article/view?id=20599 (дата обращения: 22.11.2024).