Научный журнал

European Journal of Natural History

ISSN 2073-4972

ИФ РИНЦ = 0,301

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Melchikov A.S.

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The research was carried out on 81 mature guinea-pig males, from which 51 were used in the experiment, and 30 served as the control. The experimental animals were exposed to single general irradiation (dosage - 5 Gy, filter - 0,5 mm SI, voltage - 180 kV, amperage - 10 mA, focal distance - 40 cm). Excluding the animals from the experiment and sampling the materials were done immediately, in 6 hours, on the 1^st, 5^th, 10^th, 25^th and 60^th days after finishing the exposure. Spinal ganglia were taken from different parts of spinal cord (cervical, thoracic, and lumbar). The LDH activity level in the cytoplasm of sensory neurons of spinal ganglia was subjected to the histoenzymologic research. The findings were statistically treated.

Immediately after finishing X-raying the increase of the LDH activity level in the spinal ganglia neurons of all parts of the spinal cord was marked; it being: 110,5% in the cervical part, 123,9% in the thoracic part, 109,4% in the lumbar part of the spinal cord, from the basal value (P<0,05). In the following periods the LDH activity keeps retaining increased being, in particular, 128,8% in the spinal ganglia of the cervical part, 107,8% - of the thoracic part and 104,6% - of the lumbar part of the spinal cord, from the control value (P<0,05) on the 5^th day. By the end of the observation period (60^th day) the retaining of increased LDH activity level is marked, being 154,1% in the neurons of the cervical part, 143,8% - in the thoracic part and 122,3% - in the lumbar part of the spinal cord, from the basal value (P<0,05), that testifies a significant change of LDH activity in the specified cells when being exposed to X-rays.

The article is admitted to the International Scientific Conference "Modern High Technologies", Dominican Republic, 10-20 April 2007г; came to the editorial office on 17.01.07

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