Scientific journal
European Journal of Natural History
ISSN 2073-4972

ANALYSING LIFE QUALITY OF PATIENTS WITH AN EXTENSIVE FORM OF LUNG CANCER AFTER SPECIAL TYPES OF TREATMENT

Bukenov A.M., 1 Gizbrecht E.V. 1 Orazbayev B.A. 1
1 Karaganda state medical university, regional oncological center

Results of treating 241 patients with diagnosis «lung cancer of stage IIIa-b» have been analysed. During the initial examination, an extensive form of lung cancer has been established among 97,1 % (234) of patients, and remote metastasis have been revealed among 38,6 % (93) of patients. Metastasis into regional lymph nodes have been revealed among 81,3 % (196) patients. Among those: N1 – among 28,6 % (56), N2 – among 69,9 % (137), bronchopulmonary, N3 – among 1,5 % (3), paratracheal and perioesophageal.

After verifying diagnosis of patients considering extent of disease and prediction factors, four variants of treatment have been undertaken: beam therapy – 37,7 % (91), surgery – 22 % (53), combined approach (beam therapy or neoajuvant chemical therapy + surgery) – 16,2 % (39) and complex therapy – 0,8 % (2).

Treatment efficiency has been estimated according to remote results. Five-year rate of survival equaled 22,2 ± 10,1 % per 35 radical surgeries. Survival rate in dependence on surgery volume has been reliably higher (р < 0,05) after pneumectomy than after lobectomy. One-year rate of survival equaled 85,7 ± 9,7 % and 57,1 ± 11,1 % correspondingly, three-year – 57,1 ± 13,7 % and 38,1 ± 10,8 % correspondingly. Five-year survival rate was insignificantly higher after pneumectomy than after lobectomy, 28,6 ± 26,1 % abd 19 ± 8,7 % correspondingly, the difference is statistically-insignificant.

Analysis of life quality of patients in long time period (from 1 to 5 years) has shown that relapse of bronchus stump cancer emerges among 40 % of patients (among 14 of 35 radically-operated), and among 70,5 % of patients (170 of 241 treated persons) emerges progression of tumour process with metastasis into the organ department.

Among causes of regress and decrease in life quality of patients with lung cancer in long time periods we can outline the basic ones: relapse of the disease and its further progression for 87,5 % (211) of cases, emergence of new metastasis for 86,7 % (209) of cases, and for 12,8 % (31) of cases adjunction and exacerbation of a competitive pathology can be a cause of regress in a patient’s condition. Thus, analysis of life quality has shown that adequate treatment of patient with extensive form of lung cancer is successful and prolongs life expectancy.

The work is submitted to the International Scientific Conference «Modern high technologies», Dominican Republic, April, 13–22, 2014, came to the editorial office оn 05.03.2014.