There were investigated 200 pregnant women with a high risk of intrauterine fetal infection maternity department of the Andijan regional perinatal center. The gestation time is 28–40 weeks.
High risk factors of intrauterine infection (IUI), which have diagnostic value, in addition to having a maternal history of chronic somatic diseases and inflammatory diseases of the female reproductive organs, were second pregnancy, complications during pregnancy with this threat of termination, obesity, anemia, acute respiratory infections.
Clinical high risk factors of IUI of newborns were moderate and severe conditions in the first day, degeneration of the skin and its derivatives, morphofunctional immaturity, regurgitation syndrome, impaired neonatal adaptation.
There was a significant relationship of the intrauterine infection of different etiology (enterovirus, herpes simplex virus, cytomegalovirus, influenza virus) with a history of maternal chronic disease (71,6 %), miscarriages and stillbirths (41,5 %), and such complications of pregnancy, as the threat of termination of pregnancy (37,6 %), exacerbation of chronic disease (77,5 %).
We have identified the fact that there hotbeds of acute or chronic infection in the history of women with intrauterine infection of the fetus, on the one hand, indicates the lack of specific immunological defense mechanisms and non-specific factors of resistance in the mother, and the other, is evidence of the existence of persistent infection. The main pathogenetic mechanism of disorders of the fetus is infectious factor. In the group of women with a high risk intrauterine infection fetoplacental insufficiency occurred in 35,2 %. Infectious-inflammatory diseases of pregnancy adversely affect all parts of the fetoplacental complex. Infection of the ovum is often accompanied by abortion or subsequent delay in fetal development.
The work was submitted to International Scientific Conference «Modern problems of clinical medicine», Jamaica, April, 16-26, 2013, came to the editorial office 29.04.2013.