Scientific journal
European Journal of Natural History
ISSN 2073-4972

LEVEL OF LEPTIN AND ADIPONECTIN AMONG PATIENTS WITH PODAGRA WITH METABOLIC SYNDROME

Goryainov I.I. 1 Ershva O.B. 1 Ivalkin V.E. 1 Masalova E.A. 1
1 Kursk State Medical University

The objective of this work is to study an impact of adiponectin in blood serum of patients with podagra with metabolic syndrome.

Methods and materials. 58 men with chromic podagric arthritis in an inter stroke period, aged from 40 to 60 years (average of 48,9 ± 8,2 years) have been studies; metabolic syndrome has been established among 28 of them (48,3 %). Diagnosis of podagra corresponded to classification criterions of EULAR 2010. Diagnostics of metabolic syndrome (MS) has been established according to characteristics, developed by experts of National health institute of USA (Adnet Treatment Pane lIII). Control group was formed of 24 healthy donors. Contents of leptin and adiponectin were estimated by method of immune-ferment analysis. Statistical processing of the received data was carried out with using of programme complex Statistica 8,0 for Windows.

Results and discussions. The research has shown that an increase in levels of leptin in blood serum up to 14,2 ± 1,2 ng/ml (p < 0,05), compared to the control group (4,9 ± 0,54 ng/ml) has been registered among all patients with podagra. We should outline, that contents of leptin among patients with podagra with MS exceeded that of patients without MS of 32,8 ± 2,2 % (p < 0,05).

A decrease in serum concentration of adiponectin (16,2 ± 4,8 mcl/ml) by 1,6 ± 0,2, compared to the control, was established among patients with podagra with MS, and by 1,2 ± 0,2 (p < 0,05) – compared to this index among patients with podagra without signs of MS.

Resume. Presence of MS among patients with podagra is attended by a reliably higher level of leptin in blood serum. Higher contents of adiponectin is registered among patients with podagra, compared to this index of patients who combine podagra and MS.

The work was submitted to International Scientific Conference «Fundamental and applied research in medicine», France (Paris), 14-21, October, 2012, came to the editorial office on 18.10.2012.