Scientific journal
European Journal of Natural History
ISSN 2073-4972

AGENCY OF PHENIBUTUM ON PARAMETRES OF AN ENGLOBEMENT OF RATS OF LINE WISTAR ON MODELS OF THE EXPERIMENTAL DEPRESSION

Kuleshevskaya N.R., Samotrueva M.A., Tyurenkov I.N., СHlebtsova E.B.

The variety of the clinical displays of depressive disturbances, the multiplicity of the different groups of antidepressants molecular impact mechanisms testify the participation of the linked disturbances of neurochemical systems in a depression pathogenesis. The study of the neuroimmune mechanisms of the depression development and the search for the correction means is one of the main directions of the psychoneuroimmunopathology development. We carried out an experimental research of the phenibute and phagocytal immune link impact on the experimental depression models. A pathological condition of the Wistar line male rats was formed under the conditions of emotional stress. As a result aggressors and victims with a daily experience of wins and losses were outlined within 20 intermale confrontations. Intact males that were placed separately in the same cells for 5 days and received intra-abdominal injections of physiological solution were used as a control №1. The rats with an experimental depression model that received intra-abdominal injections of physiological solution were involved in the control group №2. The research group was presented by the depressed animals that received intra-abdominal injection of phenibute in a dose of 25 ml/kg within 10 days. The study of the phagocyntal neutrophil activity was carried out on the latex test basis with the definition of phagocyntal number, phagocyntal index, and the number of active phagocytes. The phagocyntosis percent as well as the phagocyntal number rose within the depressed animals (both aggressors and victims) in comparison with the control №1. However, the absolute number of the phagocynting neytrophils within the aggressors decreased while the increase in this index was registered within the victims. The phenibute had a corrective impact on a non-specific immunity link within the research group animals: the phagocyntic number and index decreased both within the aggressors and victims and approached the "normal" animals (control №1) phagocyntic parameters, and the number of active phagocyntes tended to increase within the aggressors and decrease within the victims. The results allow us to conclude that phenibute is able to remove the disturbances of non-specific resistance that appear under the depressive conditions.


The work was submitted for the international scientific conference «Modern problems of experimental and clinical medicine», (Thailand (Pathaya)), 21-28 February 2010, came to the editorial office оn 04.02.2010.