Scientific journal
European Journal of Natural History
ISSN 2073-4972

INVESTIGATION OF MEDICINAL TEAS APPLIED IN HYPOFERRIC ANEMIA PHYTOTHERAPY

Kruglov D.S.
Drug therapy of hypoferris anemia is based on the introduction of iron from iron containing medicinal agents into the body. The substitution therapy of iron deficiency by means of its salt preparations is effective enough, however, a serious adverse events development risk, even while using modern synthetic medicinal agents, remains rather high. At the same time, phytotherapy as one of the treatment modes is deprived of disadvantages natural for drug treatment with using xenobiotic medications of synthetic origin. Phytotherapy is recommended as a means of complementary therapy and especially effective for iron deficiency prevention at hidden iron deficiency.

With that, it is necessary to note that monotherapeutic approach based on using only one from almost 200 plants used in folk medicine doesn´t allow combining etiotropic and nosotropic disease therapy. An optimal phytocomposition for anemia therapy should contain trace substances of blood-forming complex in addition to the complex of organic nature bioactive compounds (Fe, Mn, Cu, Co). To create a phytomixture of a necessary composition is possible only using several medicinal plants in the form of tea. Medicinal plant tea allows providing the required polyvalency of the pharmacological action phytopreparation.

In connection with the above mentioned to investigate the elementary composition of total abstractions from the teas most often recommended in science and folk medicine for phytotherapy appears to be of current interest. As the subjects for inquiry (table 1) the most often used in folk medicine medicinal plant teas and also the tea with a well-antianemic activity (№3) were used.

The collected medicinal plant raw material (MPR) was brought into the air-dry condition. Special medical plants were granulated as large as 1,0 mm particles. The teas were made by mixing the granulated MPR in the required for every tea proportion up to homogeneous condition. For obtaining the total abstraction an accurate batch weight of the raw material (a separate plant or their mixture as the tea ingredients) was put into a bulb. Then the raw material was poured with an extraction agent in the ratio 1:50. Distilled water was used as the extraction agent. The extraction was carried out for 2 hours on boiling water bath in a bulb with an under reflux. In the closing stage the abstraction percolation was performed and the aliquot for the micro-elementary analysis was taken away from the infiltration.

The trace element content of the blood-forming complex (being an essential component of blood-forming) - Fe, Mn, Cu and Co was defined by the method of mass-spectroscopy with inductively coupled plasma. The reproductibility of measurements was 3,0; 3,0; 10,0 and 4,0%   at Mn, Fe, Co,  and Cu concentration determining accordingly.

Table 1. Trace element content in total abstractions from MPR (mg/l).

 

 

 

 

 

№ and ingredients of the tea

Fe

Mn

Cu

Co

 

 

 

 

 

1. Betula pendula, Mentha piperita,Juglans regia- folia; Hipericum perforatum, Onopordum acanthium, Cichorium intybus, Lamium alba - herba; Juniperus communis - fructus

0,199

2,230

0,054

0,001

2. Hipericum perforatum. , Lamium alba, Achillea millifolium- herba; Fragaria vesca- folia; Avena sativa, Vaccinium myrtillus - cormi; Glycyrrhiza glabra - rizomata -

0,141

1,600

0,077

0,0004

3. Bidens tripartita, Fragaria vesca, Urtica dioica - folia; Rosa majalis - fructus

0,449

0,460

0,072

0,002

4. Betula pendula, Fragaria vesca, Urtica dioica,Ribea nigrum - folia; Rosa majalis - fructus

0,263

2,700

0,054

0,005

5. Betula pendula, Fragaria vesca, Urtica dioica,Ribea nigrum, Rubus caesius- folia; Pulmonaria obscura, Agropyron repens - herba; Avena sativa - cormi;

0,196

1,420

0,049

0,002

The micro-elementary composition of the total abstractions (table 1) testifies that for the abstractions from the tea №3 the iron and manganese contents are equal and it is this very tea that proves the antianemic activity on nosotropic mechanism of action (iron rebalancing in the body). In this connection it is necessary to note that the quotient of the standard oxidation potentials Fe3+/ Fe2+  and Mn3+/Mn2+  guarantees "in vivo" unprompted reaction of oxidation Fe2+  into Fe3+, in which the pair  Mn3+/Mn2+ will play the role of an oxidant. The ferric iron is deprived of the side effects natural for Fe2+ (citotoxicity). At the same time, finding ions Fe3+ in chelate polysaccharide complexes can prevent the carry-down of slightly soluble salts of Fe3+. The required content of the polysaccharides in the phytocomposition provides the tickseed herb (B.tripartita). In its turn, the entry of such a polysaccharide complex of Fe3+ into the body most probably will lead to activation of triad ions carrier proteins - mobilferrin and b3-integrin, that activates the iron utilization from the coming food and by this will guarantee the iron rebalancing in the body.

The article is admitted to the International Scientific  Conference  "Prior  directions of science develop-ment"; USA (New York, Washington, Miami, Las-Vegas, Los-Andzheles), October 26 - November  10, 2007г.; came to the editorial office on 23.06.07