28 persons (15 men of 50,5±3,6 years old and 13 women 56,9±2,5 years old) having suffered from insulin-dependent D of 2 type for 8,6±1,9 and 12,2±2,9 years accordingly, were examined; their hematologic indexes being studied and the erythromorphometry being carried out.
The hematologic indexes of clinically healthy men and women didn´t exceed the bounds of the conditional physiological norm. The comparative analysis revealed a higher value of erythrocytes in a blood volume unit by 14, 7%, hemoglobin - by 14, 8%, hematocrit index - by 14, 6% (p<0, 05) at the men. The mean cell value and hemoglobin concentration didn´t have authentic differences, but the tendency to higher indexes at the men was marked. Comparing erythromorphometric characteristics of healthy patients we noted that the average diameter (by 6, 3%) and average area of a cell surface (by 5, 8%) were more and the thickness index (by 11, 1%) less at the men; the mean cell volume of red blood cells didn´t have authentic differences.
The diabetic patients´ red blood indexes were in the bounds of the norm as well, but compared to the control group a more lower value of total and mean cell hemoglobin by 11, 9 and 7, 6, and 17, 8 and 8, 0 % at the men and the women accordingly. The fundamental characteristic of an erythrocyte is volume: at the diabetic patients it was lower - 94,2±0,4 and 84,3±2,34 мкм3, and 94,3±0,9 and 88,9±2,3 мкм3 (p<0,01) at the healthy and sick men and women accordingly. In the diabetic patients´ groups the diameter-thickness ratio was authentically higher and the specific surface area was lower, the differences being graded more vividly at the women than at the men.
- blood of clinically healthy men contains more erythrocytes and hemoglobin in a blood unit volume than that of women, and it has a more higher hematocrit index;
- sex specificity of the main hematologic indexes retains at the diabetic patients;
- specific and average surface areas and the average volume of an erythrocyte is lower , but diameter-thickness ratio is higher at the patients;
- geometric profile changes of red blood cells decreases their contribution in normal functioning of homeostatic systems of a body at diabetes;
- hematologic profile and morphometric characteristics´ changes of erythrocytes at diabetic patients are valued as adaptive processes aimed at blood flow properties perfecting and reducing tissue hypoxia in erythron system.
The article is admitted to the V International Scientific Conference "Modern High Technologies"; Egypt, Hurgada, February, 21-28, 2007; came to the editorial office on 11.01.07