The purpose of our work was to reveal special health features of parents and primogenitors of the girls with menstrual function formation infringement in their puberty. The estimation of anamnestic and clinical characteristics of 232 married couples of mothers and the fathers having daughters with the menstrual function formation infringement, and also 232 married couples of grandmothers and grandfathers on the maternal side has been carried out.
Parents (116) and primogenitors (116) of 15-18-year-old girls with the menstrual function formation infringement in their puberty formed the basic group. Married couples of parents (116) and primogenitors (116) of girls with physiological puberty formed the comparison group. While estimating the distinctions Student t-criterion was used.
In the basic group of mothers the significant increase of somatic and gynecologic diseases has been revealed, the last having appeared in their reproductive age. Authentically the diseases of ENT-organs 90 (77,6 %), cardiovascular 97 (83,6 %), endocrine 99 (85,3 %), digestive 64 (55,2 %) and respiratory 34 (29,3 %) systems occurred more often. At mothers in the comparison group the diseases of these systems occurred accordingly 29 (25,0 %), 46 (39,7 %), 33 (28,4 %), 19 (16,4 %), 13 (11,2 %). From gynecologic diseases in the basic group of mothers authentically more often the background disease of uterine cervix 67 (57,8 %), menstrual period infringements 46 (39,7 %), inflammatory true pelvis diseases 56 (48,3 %) and benign new growths of uterus and ovaries 40 (34,5 %) occurred. At mothers having daughters with physiological puberty the diseases occurred accordingly 42 (36,2 %), 20 (17,2 %), 32 (27,6 %) and 11 (9,5 %).
In the group of fathers having daughters with the menstrual function formation infringement, the authentic increase of diseases of bronchi-pulmonary system 53 (45,7 %) has been noted, in the comparison group these diseases being noted less often 36 (31,0 %). Grandmothers of the basic group suffered authentically more often from the diseases of cardiovascular 94 (81,0 %), endocrine 77 (66,4 %), digestive 55 (47,4 %) systems, whereas grandmothers of the comparison group suffered from those accordingly 26 (22,4 %), 28 (24,1 %), 26 (22,4 %). The grandmothers having grand daughters with the menstrual function formation infringement, authentically more often had benign and malignant new growths of reproductive organs 44 (37,9 %), in the comparison group - accordingly 12 (10,3 %). Grandfathers of the basic group suffered authentically more often from the diseases of cardiovascular 90 (77,6 %), bronchi-pulmonary 60 (51,7 %) and nervous 39 (33,6 %) systems, whereas in the comparison group grandfathers suffered from the same diseases twice as less often 45 (38,8 %), 39 (33,6 %), 15 (12,9 %) (p <0,05).
Thus, somatic and reproductive diseases of girls´ parents and primogenitors are a negative background for their reproductive function formation. The realization of the gene program is shown in the immune and homeostatic trouble in parents´ and primogenitors´ generations and defines girls´ menstrual function formation infringements in their puberty.
The article is admitted to the International Scientific Conference "Modern Problems of Experimental and Clinical Medicine", Thailand, 2007, January 17-28; came to the editorial office on 30.10.06.