There is a great number of the facts, indicating at the close integration of the central nervous system, its coordination infringement is playing the important role in the development as the neuromental, as the immune disorganize. The great importance is been attaching to the reseaches, touching on the influence of the psychopharmacological medicine at the immune status parameter. In this research we have made the studying of the phenibut and its derivates influence laboratory code RGPU-149, RGPU-150 and RGPU-151 at the organizing of the reaction hypersensitivity of the delayed-model (RHDT) with the experimental immune deficit.
The research has been made with 60 mice of the line CBA mass 18 - 20 g. The animals were distributed on the groups (n = 10); control № 1 - the immunizing animals, receiving phys. solution; control № 2 - immunizing animals with the immunedeficit model (cyclophosphamid (CPh) in the doze 100 mg/kg); experienced groups - the immunizing animals with the immune depression, receiving phenibut inside - intraperitoneal in the therapeutic doze 25 mg/kg and its derivate: RGPU-149 (47,6 mg/kg), RGPU-150 (49,2 mg/kg) and RGPU-151 (48,1 mg/kg). For phenibut derivates the doze is 1/10 from LD50.
The Results of the study are presented in table.
Table 1. The influence of phenibut and its derivate at RHDT forming in the conditions of the experimental immunesuppression
|
Animal groups
|
Control 1: (phys.solution): n = 10 |
Control 2: CPH n = 10 |
Experimental I: PHEN1BUT+ CPh n = 10 |
Experimental 2: RGPU-149+ CPh n = 10 |
Experimental 3: RGPU-150+ CPh n = 10 |
Experimental 4: RGPU-151+ CPh n = 10 |
|
Index RHDT, M ± m, %
|
11,4 ± 0,5 |
8,2 ± 0,6***
|
19,7 ± 2,7*
|
21,5 ± 1,5***
|
31,7 ± 2,4***
|
26,5 ± 4,4***
|
In the course of the carried out tests it was fixed that the single inside intraperitoneal leading cyclophosphamid is conducire to the suppression of the cell reaction of the delayed type (reaction index below control № 1 in 1,5 times). The leading of phenibut and its derivates to animals with the immunesuppression model is accomponing with the stimulating action with the regard to the cell section of the immune reactivity, it reveals itself with the increase of the reaction index RHDT more than 50% not only by comparison with the animals from the control group № 1 (p<0,05), but more than 40% with respect to the exponents in the mice groups, receiving «placebo» (p<0,05).
So, phenibut and its derivates with the laboratory codes RGPU-149. RGPU-150 and RGPU-151 are removing pharmacoinduced immune deficiency, it is evidence of the immunecorrecting qualities presence. The present conclusion allows to regard the learning substances as the perspective ones as the means of the correction of the neuroimmune pathology.
The work was submitted to international scientific conference «Basic and applied problems meditsyny and biology», UAE (Dubai), 15-22 October 2008. Came to the editorial office on 19.08.2008.