In recent years, the trend of increased incidence of psoriasis. One of the pathogenetic elements in the development of psoriatic disease is an imbalance in the processes of lipid peroxidation (LPO). Studies confirm that the inflammation and the stress associated with activation of lipid peroxidation, which may indicate the severity and extent of pathological process. However, the literature lacks data on the relationship between gender and rational farmakokorrekthion of severe psoriasis.
The purpose of the study - the identification of particular changes in lipid peroxidation in patients with psoriasis, psoriatic arthritis (PA) and psoriatic eritrodermy (PE) on the background of traditional therapy.
Materials and methods. A study performed with the participation of 96 patients with psoriasis in the phase progression of the process on the basis of the Kursk Regional Clinical STI clinic. In the control group included 30 healthy persons, representative for age and sex. Clinical and laboratory studies (malondialdehyde (MDA), superoxide dismutase (SOD)) conducted before and after the course of traditional therapy to conventional standard methods. To evaluate the clinical efficacy of treatment using the calculation of the index PASI. Statistical processing of the data was carried out using the program "Statistica 6.
The results of the study. Studies have shown that the MDA had a tendency to increase in the survey group. Maximal changes in MDA (4,36 ± 0,08 mol / l; p <0,05) were observed in patients with PA, the index of PASI they amounted to 52,4. In remission after treatment (index of PASI = 7,8), decreased rates of activity MDA to 3,78 ± 0,12 mol / l (p <0,05).
Conclusions. Clinical forms of psoriasis, the incidence of the skin, the duration of the next exacerbation, severity of current dermatosis is directly dependent on the processes of lipid peroxidation. Evaluation of gravity flow of psoriasis (with an index PASI) were important criteria for stratification of rational pharmacotherapy of patients. Application of an integrated standard psoriasis therapy in the phase progression of the disease improves quality of life.
The work is submitted to Scientific Conference "The Problems of International Integration of Educational Standards", England (London) - France (Paris), April 20-28, 2009. Came to the Editor´s Office on 27.02.2009.