Scientific journal
European Journal of Natural History
ISSN 2073-4972

FUNCTIONAL DISREGULATION OF PERITONEUM AT VARIOUS INTENSITY OPERATIONAL TRAUMAS

Vorobyev A.A., Poroysky S.V, Мaksimova I.A, Zasypkina O.A, Dvoretskaya Y.A.

Introduction: The influence of an operational trauma on the peritoneal operant behavior up to the present moment is still an insufficiently explored problem.

Purpose: To define the operational trauma dimensions´ influence on the peritoneal resorption.

Materials and methods: A new experimental model allowing estimating the peritoneal resorptive capacity was developed, patented and applied. There were 90 sexually mature Wistar female rats involved in the experiment. To evaluate the peritoneal physiological resorptive capacity the intact animals were administered a standard dose of the ethaminal solution (40 mg/kg) throughout 4 days intraperitoneally. On the 4th day all the animals were exposed to a surgical intervention: 1 group - a standard operational trauma, 2 group - subtotal hysterectomy and 3 group - total hysterectomy. The peritoneal resorptive function was evaluated indirectly by means of intraperitoneal ethaminal introduction and measurement of the time length necessary for the surgical sleep to begin for 7 days.

Results: the peritoneal resorptive function research experimental model application defined that the time of physiological resorption made 5,15±0,89 min in the intact animals. The resorption at the various intensity operational traumas made: in the 1 group: 1 day - 9,8±0,5; 2 day - 8,2±0,7; 3 day - 7,1±0,7; 4 day - 5,8±0,7; 5 day - 5,2±0,5; 6 day - 5,1±0,7; 7 day - 5,1±0,5; in the 2group: 1 day - 10,1±0,6; 2 day - 9,0±0,5; 3 day - 7,8±0,6; 4 day - 6,8±0,4; 5 day - 6,1±0,4; 6 day -5,1±0,4; 7 day - 4,8±0,7; in the 3group: 1 day - 11,3±1,0; 2 day - 9,3±1,7; 3 day - 8,3±0,7; 4 day - 7,3±0,5; 5 day - 6,5±0,5; 6 day - 5,8±0,4; 7 day -5,1±0,4.

Conclusions: So, the peritoneum responses to the operational trauma in the form of the peritoneal resorptive function inversive decline, a direct dependence of functional disorders´ degree on the operational trauma´ intensity being found out.

The work was submitted to international scientific conference «Homeostasis and endoecology», Egypt (Sharm el-Sheikh), February 20-27, 2009. Came to the editorial office оn 23.01.2009.