According to the World Health Organization mammary gland cancer in women is the first (as far as localization is concerned) in the structure of morbidity which constitutes 18% of the total number of malignant tumours. In order to decrease morbidity it is necessary to investigate different ways of influence on the mammary gland precancer processes to which cystic mastopathy is related.
In the intact series veroshpiron contributes to development of the mammary glands. Under its influence there is slight enlargement of the ducts, height of the epithelium and increase in secretion. In case of cystic mastopathy 4 week course of veroshpiron in therapeutic doses causes manifested regress of the cysts. There is complete reverse development of the cysts. The ducts are in big groups making lobules. The ducts are much narrowed and lined with cuboidal epithelium. The lumens of them are hardly distinguished. The scheme of introduction of potentias of veroshpiron:
- Group 1 - 6C 3 times a day during a month
- Group 2 -6С, 12С, 30С 3 times a day during a month
- Group 3 - 30C 3 times a day during a month
We investigated mammary glands in 25 virgin females of not thoroughbred white rats which were conditionally divided into 3 groups of experiment and 2 groups of control. Groups of the experiment got homeopathic veroshpiron according to 3 schemes perorally during a month. Groups of the control - group 1 cystic mastopathy control and group 2 cystic mastopathy control 1 month later after its receipt. Cystic mastopathy model with hexestrol introduced - control 6 weeks later: dilation of the ducts is cyst-shaped. They are lined with flattened epithelium. There are protein-fat masses in the lumens of the cysts.
Cystic mastopathy control 4 weeks later after its receipt: the ducts dilation of which is cyst-shaped are lined with flattened epithelium. The secret is sporadically present in the lumens. The other cysts have no contents.
The first group of the experiment with cystic mastopathy that got potentia 6С 3 times a day: the ducts are in groups of 10-12 ducts making lobules. The ducts are narrowed. Epithelium is cuboidal.
One of the observations shows incomplete regress of the cysts
- The duct is dilated to some extent
- Epithelium is cuboidal
- There is a little amount of the secret in the lumen
- The duct is surrounded by small streaks of fibrous tissue
The second group of the experiment with cystic mastopathy that got 6C, 12C, 30C 3 times a day: the ducts are in groups. Each group consists of 20-22 ducts in the form of a lobule. The ducts are narrowed. The lumens are slightly distinguished.
Mammary gland stroma: vessels are much dilated and with blood congestion.
Manifested regress of the cysts. The ducts are in small groups. Epithelium is cuboidal. There is remnant of the secret in the lumens.
Incomplete regress of the cysts. Along with much narrowed ducts with cuboidal epithelium there are few dilated ducts the lumens of which contain a little amount of secret.
The third group of the experiment with cystic mastopathy that got 30C 3 times a day. Manifested regress of the cysts. The ducts are in small groups. Epithelium is cuboidal. The ducts are narrowed.
Transitional stage of the regress of the big cyst. The ducts are jellyfish-shaped. Epithelium is cuboidal. There is remnant of the secret in the lumen.
Incomplete regress of the cysts against the background of wave scheme of introduction of homeopathic veroshpiron. Simultaneously dilated ducts with flattened epithelium, in the lumen there are protein-fat masses. The areas with much narrowed ducts with cuboidal epithelium.
Veroshpiron in homeopathic dilutions exerts its influence on the mammary glands with cystic mastopathy. Many observations show quite a high grade of regress in comparison with the control. Few observations show incomplete regress, but influence of veroshpiron causes restoration of the epithelium to the norm in comparison with the control. According to the mechanism of action veroshpiron is the similar preparation in hexestrol model of cystic mastopathy.
The results are of interest for oncologists and mammologists. Veroshpiron will be further applied in restorative medicine by joint efforts with international academy of classic homeopathy. It will be used in treatment of the patients with diseases of mammary glands in a homeopathic clinic.
The work was submitted to international scientific conference «Present-day problems of experimental and clinical medicine», Thailand - Cambodia, February 18-28, 2009. Came to the editorial office on 02.02.2009.